ICCF - MPS : Materials For Health

Magnetic and bioactive heterostructures for bone cancer treatment through magnetic hyperthermia.

The Tissue Repair and Engineering group project aims bone tissues particularly and the musculoskeletal system more generally. This approach associates an extracellular matrix (scaffold), osteogenic cells (mainly mesenchymal stem cells) and an appropriate environment in terms of biological signals and vascularisation (growth factors …). For the matrix, the materials biological quality improvement is pursued via three approaches:

• Hierarchical and controlled porosity to improve mechanical resistance, physical/structural attachment and bone tissue integration (osteo-integration notion)
• Surface functionalization for the vectorization of active ingredients or molecules with a biological effect, like BMP, integrins, growth factors … (osteo-induction notion)
• Material doping with elements allowing, through a controlled release kinetic, to trigger a localized and targeted biological response (anti-bacterial, anti-inflammatory, anti-osteoporotic effects …). Core-shell heterostructures synthesis based on magnetic nanoparticles surrounded by bioactive glass, aiming bone cancer treatment through magnetic hyperthermia.

Bioactive glasses and phospho-calcite ceramics, high-potential candidates, are synthesized by a sol-gel route so that their chemistry, morphology and shapes could be finely controlled. From a cellular point of view, the aim is to continue the works based on human mesenchymal stem cells. The idea here is to potentialized or to orientate their action through the modification of their environment, while studying the effects of functionalized matrixes and topographical or surface chemistry modifications. This aspect also includes the detection of potentially harmful effects generated (cytotoxicity), or the study of the effects on non-eucaryote cells (anti-bacterial properties).

Other GCCA partners

• UNH : Human Nutrition Research Unit