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iGReD : Institute of Genetics, Reproduction & Development

iGReD
INSERM U1103 CNRS6293
Centre de Recherche et de Biologie Clinique - CRBC
28, Place Henri Dunant
63000 Clermont-Ferrand
www.gred-clermont.fr/
Head : Krzysztof JAGLA

RESEARCH ACTIVITIES WITHIN THE GCCA

iGReD - Environment, Metabolism, Sermatogenesis, Pathophysiology and Inheritance

Testicular germ cell tumors (TGCT) is the most common cancer in young men. Its incidence has increased over the last decades. The identification of the actors involved is essential, as 10% of the patients die from their cancer. Our objective is to identify the signaling pathways involved in TGCT.
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iGReD - Epithelial growth and morphogenesis

We use the Drosophila model to study generic aspects of the biology of epithelia such as the control of their growth (proliferation, cell size, homeostasis) and their morphogenesis (cell and tissue shapes and polarities) in a developmental context or mimicking a pathological situation.
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iGReD - Genomic Imprinting and the epigenetic control of cell fate determination

Epigenetic bases of gene transcriptional deregulation in malignant glioma.
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iGReD - Molecular Pathophysiology of Adrenal and Endocrine Tissues (MOP@ET)

Through the development of genetically engineered mouse models, our team deciphers the molecular mechanisms resulting in development and progression of adrenocortical carcinoma, a rare cancer of the adrenal gland.
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iGReD - NuReP – Nuclear Receptor and Pathophysiology

The research activity of our group aims to better understand the consequences of cholesterol metabolism deregulation in the initiation, promotion and development of prostate cancer (CaP). Thus, our research activity focuses on the metabolic reprogramming of prostate tumors at each stage of the disease.
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iGReD - REpigenetic regulations and hematopoiesis / REpiH

Our objective is to decipher the transcriptional and post-transcriptional mechanisms of regulation of gene expression by epigenetic enzymes involved in blood cell development and whose activity is altered in blood cell cancers
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iGReD - Telomeres and cancer

All cancer cells absolutely require reactivation of telomere maintenance mechanisms in order to proliferate. We currently study the telomeric CST complex (Cdc13-Stn1-Ten1) in a model system, the yeast S. cerevisiae. In addition, we collaborate with clinicians by measuring telomeric parameters in tumor samples.
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Translations

iGReD : Institute of Genetics, Reproduction & Development

RESEARCH ACTIVITIES WITHIN THE GCCA

iGReD - Environment, Metabolism, Sermatogenesis, Pathophysiology and Inheritance

iGReD - Epithelial growth and morphogenesis

iGReD - Genomic Imprinting and the epigenetic control of cell fate determination

iGReD - Molecular Pathophysiology of Adrenal and Endocrine Tissues (MOP@ET)

iGReD - NuReP – Nuclear Receptor and Pathophysiology

iGReD - REpigenetic regulations and hematopoiesis / REpiH

iGReD - Telomeres and cancer

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iGReD : Institute of Genetics, Reproduction & Development

RESEARCH ACTIVITIES WITHIN THE GCCA

iGReD - Environment, Metabolism, Sermatogenesis, Pathophysiology and Inheritance

iGReD - Epithelial growth and morphogenesis

iGReD - Genomic Imprinting and the epigenetic control of cell fate determination

iGReD - Molecular Pathophysiology of Adrenal and Endocrine Tissues (MOP@ET)

iGReD - NuReP – Nuclear Receptor and Pathophysiology

iGReD - REpigenetic regulations and hematopoiesis / REpiH

iGReD - Telomeres and cancer