iGReD - REpigenetic regulations and hematopoiesis / REpiH

Confocal image of the Drosophila larval hematopoietic organ. Blood cell progenitors are shown in green and their differentiated progenies in blue and red.

We are particularly interested in understanding the function and mode of action of epigenetic enzymes that control gene expression and genome metabolism by modifying DNA and/or RNA and whose activity is altered in leukemia and lymphoma.

Our researches rely on a combination of approaches ranging from genetic (transgenesis, CRISPR, RNAi, genetic screens), molecular biology (ChIP-seq, RNA-seq, SMRT-seq, HiC…) and developmental biology (confocal imaging, cell lineage analyses…) using Drosophila as a model organism. Our goal is to characterise the cellular and developmental phenotypes associated with mutations in epigenetic enzymes and their relationships with gene expression modification and/or genome organisation.

Our researches will shed deep insights on the molecular mechanisms of actions of these conserved epigenetic enzymes and could open new leads to fight cancers.

Other GCCA partners

• Clermont-Ferrand University hospital - Haematology Department
• CHELTER - Role of intra-Clonal HEterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias